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Distribution patterns Once absorbed, the distribution of these compounds throughout the body significantly impacts their therapeutic effects

In vitro experiments revealed reduced HIF-1 expression and transcriptional function following rapamycin treatment, while in vivo models showed significant inhibition of tumor vascularization and growth (199)

ROS damage to oocytes, sperm, and embryos, and prevention by antioxidants Oocytes Aberrations in microtubule integrity, abundance, and alignment at the metaphase plate have been shown to increase susceptibility to errors in meiotic chromosome segregation in animal oocytes, and may do so in human oocytes, and embryos ( 59 64 )

Kovalchuk AL, Qi CF, Torrey TA, Taddesse-Heath L, Feigenbaum L, Park SS, et al